During my scientific career I have mainly focused on the study of prognostic biomarkers to identify cancer patients at high risk of relapse after surgery and/or chemoresistant patients. To identify these patients, I first focused on pharmacogenomics. The study of polymorphisms and mutations in genes related to treatment metabolism and DNA repair occupied my first years of research.
After that stage, we started to study the role of microRNAs in Cancer, and recently I have extended my studies to other groups of non-coding RNAs, including lncRNAs, circRNAs or piwiRNAs.
I have worked on several tumor models, including solid and hematological malignancies, but now I am centered on the study of non-coding RNAs in lung cancer.
I am also working with liquid biopsies and extracellular vesicles (exosomes), and recently I have begin to study embryonic and patient-derived lung cancer organoids.
Interests: noncoding RNAs; microRNAs; piwiRNAs; lncRNAs; circularRNAs; extracellular vesicles; exosomes; biomarkers; lung cancer; colorectal cancer; lymphoma; leukemia; Hodgkin lymphoma; Multiple myeloma; organoids;
To see a list with all of Alfons Navarro’s papers you can visit Google Scholar or Alfons’s ORCID 0000-0001-6071-0926
Below we have included selected papers describing some of our best known work.
-Epigenetic regulation mechanisms of microRNA expression. S Morales, M Monzo, A Navarro. Biomolecular concepts 8 (5-6), 203-212.
-Non-coding RNAs in Hodgkin lymphoma. A Cordeiro, M Monzó, A Navarro. International journal of molecular sciences 18 (6), 1154.
-MIR135A1 (microRNA 135a-1). A Navarro, M Díaz-Beyá, M Monzó. Atlas of Genetics and Cytogenetics in Oncology and Haematology.
-MicroRNAs in human embryonic and cancer stem cells. A Navarro, M Monzó. Yonsei medical journal 51 (5), 622-632.
-Pharmacogenomics: a tool for improving cancer chemotherapy. M Monzo, A Navarro, G Ferrer, R Artells. Clinical and Translational Oncology 10 (10), 628-637.
-Deciphering miRNA–Target Relationships to Understand miRNA-Mediated Carcinogenesis. A Navarro. Cancers 2021, 13(10), 2415.
-Editorial: The Role of ncRNAs in Solid Tumors Prognosis: From Laboratory to Clinical Utility.. Zhou J-G, Huang Z, Slaby O and Navarro A Front. Oncol. 2021, 10:631316.
-Clinic and therapeutic potential of non-coding RNAs in cancer. JJ Castellano, M Diaz-Beya, A Navarro. Transl Cancer Res 10 (6).
-Can long non-coding RNAs reveal the hidden code of lung cancer?. JJ Castellano, A Navarro. Non-coding RNA Investigation, 2020, vol. 4, num. 6.
-Twist1 activated circRNA-10720 is a new player in hepatocellular carcinoma metastasis. A Navarro. Transl Cancer Res 8 (S2), S135-S140.
-Argonaute-crosslinking and immunoprecipitation deciphers the liver miR-122 targetome. A Navarro. Non-coding RNA Investig 1, 23.
-Genotypes and chemotherapy toxicity. M Monzo, A Navarro. Pharmacogenomics vol. 10, num. 3.
-Genetic Predictors of Leukocytopenia severity. M Monzo, A Navarro. Pharmacogenomics vol. 10, num. 3.
-miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer. E Gallardo, A Navarro, N Vinolas, RM Marrades, T Diaz, B Gel, A Quera, … Carcinogenesis 30 (11), 1903-1909.
-Overlapping expression of microRNAs in human embryonic colon and colorectal cancer. M Monzo, A Navarro, E Bandres, R Artells, I Moreno, B Gel, R Ibeas, … Cell research 18 (8), 823-833.
-MicroRNA expression profiling in classic Hodgkin lymphoma. A Navarro, A Gaya, A Martinez, A Urbano-Ispizua, A Pons, O Balagué, … Blood, The Journal of the American Society of Hematology 111 (5), 2825-2832.
-Regulation of JAK2 by miR-135a: prognostic impact in classic Hodgkin lymphoma. A Navarro, T Diaz, A Martinez, A Gaya, A Pons, B Gel, C Codony, G Ferrer, … Blood, The Journal of the American Society of Hematology 114 (14), 2945-2951.
-Acute myeloid leukemia with translocation (8; 16)(p11; p13) and MYST3-CREBBP rearrangement harbors a distinctive microRNA signature targeting RET proto-oncogene. M Diaz-Beya, A Navarro, G Ferrer, T Diaz, B Gel, M Camos, M Pratcorona, … Leukemia 27 (3), 595-603.
-MicroRNA expression at diagnosis adds relevant prognostic information to molecular categorization in patients with intermediate-risk cytogenetic acute myeloid leukemia. M Diaz-Beya, S Brunet, J Nomdedeu, R Tejero, T Diaz, M Pratcorona, … Leukemia 28 (4), 804-812
-LincRNA-p21 impacts prognosis in resected non–small cell lung Cancer patients through angiogenesis regulation JJ Castellano, A Navarro, N Viñolas, RM Marrades, J Moises, A Cordeiro, … Journal of Thoracic Oncology 11 (12), 2173-2182.
-PiwiRNA-651 as marker of treatment response and survival in classical Hodgkin lymphoma A Cordeiro, A Navarro, A Gaya, M Díaz-Beyá, B Gonzalez-Farré, … Oncotarget 7 (29), 46002-46013.
-The significance of PIWI family expression in human lung embryogenesis and non-small cell lung cancer A Navarro, R Tejero, N Viñolas, A Cordeiro, RM Marrades, D Fuster, … Oncotarget 6 (31), 31544.
-Role of the epithelial-mesenchymal transition-related circular RNA, circ-10720, in non-small-cell lung cancer. J Martín, JJ Castellano, RM Marrades, J Canals, N Viñolas, T Díaz, … Translational Lung Cancer Research 10 (4), 1804
-Extracellular vesicle lincRNA-p21 expression in tumor-draining pulmonary vein defines prognosis in NSCLC and modulates endothelial cell behavior JJ Castellano, RM Marrades, L Molins, N Viñolas, J Moises, J Canals, … Cancers 12 (3), 734
-Exosome analysis in tumor-draining pulmonary vein identifies NSCLC patients with higher risk of relapse after curative surgery A Navarro, L Molins, RM Marrades, J Moises, N Viñolas, S Morales, … Cancers 11 (2), 249
-Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation. CF de Larrea, A Navarro, R Tejero, N Tovar, T Díaz, MT Cibeira, L Rosinol, … Clinical cancer research 18 (13), 3697-3704.
-Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. M Monzo, S Brunet, A Urbano-Ispizua, A Navarro, G Perea, J Esteve, … Blood 107 (12), 4871-4879.
-MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin lymphoma patients. A Navarro, C Munoz, A Gaya, M Díaz-Beyá, B Gel, R Tejero, T Díaz, … PloS one 8 (5), e64716
-A dual role for KRT81: a miR-SNP associated with recurrence in non-small-cell lung cancer and a novel marker of squamous cell lung carcinoma. M Campayo, A Navarro, N Vinolas, R Tejero, C Munoz, T Diaz, … PloS one 6 (7), e22509
-Single-nucleotide polymorphisms in base excision repair, nucleotide excision repair, and double strand break genes as markers for response to radiotherapy in patients with … J Carles, M Monzo, M Amat, S Jansa, R Artells, A Navarro, P Foro, … International Journal of Radiation Oncology* Biology* Physics 66 (4), 1022-1030.
-Common variants in NLRP2 and NLRP3 genes are strong prognostic factors for the outcome of HLA-identical sibling allogeneic stem cell transplantation M Granell, A Urbano-Ispizua, A Pons, JI Aróstegui, B Gel, A Navarro, … Blood, The Journal of the American Society of Hematology 112 (10), 4337-4342